Despair

To be hopeless; to have no hope; to give up all hope or expectation; -- often with of.

To give up as beyond hope or expectation; to despair of.

To cause to despair.

Loss of hope; utter hopelessness; complete despondency.

That which is despaired of.

the feeling that everything is wrong and nothing will turn out well; "they moaned in despair and dismay"; "one harsh word would send her into the depths of despair"

a state in which all hope is lost or absent; "in the depths of despair"; "they were rescued from despair at the last minute"; "courage born of desperation"